Please use this identifier to cite or link to this item: https://idr.l4.nitk.ac.in/jspui/handle/123456789/12778
Title: Regioselective reaction: Synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles
Authors: Isloor, A.M.
Kalluraya, B.
Shetty, P.
Issue Date: 2009
Citation: European Journal of Medicinal Chemistry, 2009, Vol.44, 9, pp.3784-3787
Abstract: In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, 1H NMR, mass spectral data and elemental analyses. These compounds were screened for their antibacterial and antifungal activity. Some of the compounds were found to exhibit significant antimicrobial activity. 2009 Elsevier Masson SAS. All rights reserved.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/12778
Appears in Collections:1. Journal Articles

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