Please use this identifier to cite or link to this item: https://idr.l4.nitk.ac.in/jspui/handle/123456789/10238
Title: Cocrystals of Ethenzamide: Study of Structural and Physicochemical Properties
Authors: Hariprasad, V.M.
Nechipadappu, S.K.
Trivedi, D.R.
Issue Date: 2016
Citation: Crystal Growth and Design, 2016, Vol.16, 8, pp.4473-4481
Abstract: Pharmaceutical cocrystals of an analgesic drug ethenzamide (ETZ) with various coformers, namely, gallic acid (GA), 2-nitrobenzoic acid (2NB), 3-nitrobenzoic acid (3NB), 2,4-dinitrobenzoic acid (DNB), and 3-toluic acid (3TA) were synthesized by the solvent evaporation method. All the cocrystals were characterized by various analytical techniques, and the crystal structures were determined by the single-crystal X-ray diffraction method (SCXRD). SCXRD analysis revealed that all the synthesized cocrystals were formed through a robust supramolecular acid-amide heterosynthon except the ethenzamide/gallic acid cocrystal, where molecules interacted through O-H O hydrogen bond involving -OH of gallic acid and oxygen of amide group of the ETZ molecule. The physicochemical properties such as stability, hygroscopicity, and solubility studies of the ETZ-GA cocrystal were evaluated. It was found that the ETZ-GA cocrystal has a higher solubility (2-fold) than that of the pure ETZ drug molecule. Hygroscopic study of the ETZ-GA cocrystal revealed that synthesized cocrystal was non-hygroscopic at ?75% RH conditions. The ETZ-GA cocrystal found to be stable for a time period of four months at ambient temperature. 2016 American Chemical Society.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/10238
Appears in Collections:1. Journal Articles

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