Solvent-free synthesis of bis-hydrazones through 1,3-dipolar cycloaddition of sydnone and study of their optical, molecular docking, and antioxidant properties

Abstract

A series of new 1-(aryl)-1H-pyrazol-3,4-bis (aryl)-3,4-dicarbohydrazones (4) was obtained by the condensation of 1-arylpyrazole-3,4-dicarbohydrazides (3) with various aryl aldehydes under solvent-free conditions. The structures of the newly synthesized hydrazones were confirmed by proton-nuclear magnetic resonance spectroscopy, infrared spectroscopy, liquid chromatography mass spectrometry, elemental analysis, and by single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant activity, where compound 4a has shown percentage inhibition higher than the standard butylated hydroxyanisole. The molecular docking and photophysical property were also investigated. 2018 Connect Journals.